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KMID : 0362220100370020107
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Journal of The Korean Research Society for Dental Materials
2010 Volume.37 No. 2 p.107 ~ p.114
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Effect of Na and F Elements on the Solubility and Cell Viability in Calcium Phosphate Glass
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Kim Min-Chul
Lee Byung-Hyun
Kim Kyoung-Nam
Kim Kwang-Mahn
Lee Yong-Keun
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Abstract
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The development of phosphate glasses for clinical applications has attracted much interest because their
chemical and physical properties make them suitable for use as bone-graft materials. We prepared various
compositions of CaO-P2O5-CaF2-Na2O glass system by conventional melting process. The objective of this work
was to investigate the effect of sodium and fluorine elements on calcium phosphate glasses for bone regeneration
by measuring solubility and biological response. Atomic ratio of (Ca+Na)/P and a content of P2O5
were fixed at 0.6 and 45.45 mol%, respectively. To measure solubility, the pellet was kept into 30 mL of distilled
water. At the same time as the solubility measurements, the pH of the solution was also measured. Ca,
P, and Na ion dissolution were measured by Inductively Coupled Plasma Atomic Emission Spectrophotometer
and the release of F ion was determined using Fluoride Ion Selective Electrode. Biological response of glass extracts
was measured using WST-1 method. Glasses with high content of sodium oxides showed larger solubility
rate, but in case of glasses with F element, there were few changes. The dissolved amount of Ca and P ion was
related to solubility; with high solubility, the dissolved amount was increased. Except for glass with CaF2 and
Na2O content of each 9 mol%, with increasing added oxides content and time, the pH value tended to be lower.
pH values decreased with P ion content increasing. The viability of MG 63 cell in glass extracts of 2 weeks
showed above 90%.
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KEYWORD
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Calcium phosphate, Solubility, Dissolution, Ion release, Cell viability
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